Jeste li znali da je Avon prva kompanija koja je počela koristiti stabilan retinol u svojim kozmetičkim proizvodima? U Avon laboratorijima u Suffernu, Big apple znanstvenici su sada došli i do još većeg otkrića – Protinola – koji paralelno potiče proizvodnju 2 tipa kolagena i tako dodatno učvršćuje i obnavlja kožu lica.
Fileri nove generacije traju 18 meseci, zato proverite koji preparat ubrizgavate i koliko će vas to dugoročno koštati Lepota kao imperativ vremena: niko ne želi bore ni staro lice
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Summary in English, French Objective: Facial skin undergoes main structural and purposeful adjustments due to intrinsic and extrinsic components. The aim of the current do the job is always to display L-4-thiazolylalaine (L4, Protinol), a non-proteinogenic amino acid proven to encourage the manufacture of dermal proteins by fibroblasts, is an alternative efficacious topical component for seen signs of ageing. Methods: In vitro scientific studies making use of 3D human skin tissue versions had been executed to show modifications in protein and gene expression of important dermal markers in samples addressed with 0.3% L4 in comparison with car Regulate. In vivo analysis of skin turnover was calculated in volunteers immediately after therapy with L4 in comparison to retinol. Skin biopsies (n = 30) have been taken to research epidermal and dermal modifications in situations addressed with L4 and when compared with retinol. At last, a clinical analysis (n = 28) was executed to assess the efficacy of L4 above a base formulation utilizing a variety of ageing parameters in just a populace of girls 46-sixty six yrs previous with mild-to-average wrinkles. Effects: In vitro scientific tests on 3D tissues displayed substantial variations inside the dermal matrix via an increase in HA and Professional-collagen I production in addition to a lower in the expression of inflammatory genes. In vivo biopsy studies demonstrated that L4 and retinol independently enhanced epidermal thickness and collagen remodelling considerably additional in contrast with the base method. Clinical evaluation confirmed firmer and smoother skin at working day 28 post-treatment method with L4 over the automobile Management without the need of causing Unintended effects such as redness or discomfort. Conclusion: L4 is really a novel, multi-functional ingredient which provides a remarkable choice to currently available systems for strengthening epidermal and dermal parameters that transform through ageing and photodamage. Objectif: La peau du visage est sujet à des changements majeurs structuraux et fonctionnels dus à des facteurs intrinsèques et extrinsèques. Dans cette étude, nous montrons que l'acide aminé non-protéinogène L-4-thiazolylalanine (L4, Protinol) est une choice intéressante pour une application topique.
ProtinolTM je jedinstvena kombinacija aminokiselina koja pomaže u održavanju savršene ravnoteže kolagena. Pored kolagena tipa I, koji koži daje elastičnost, izuzetno je važan i kolagen tipa III, koji je najzastupljeniji u bebinoj koži i značajan je za formiranje i funkcionisanje kolagena tipa I.
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Collagen III is just like the matrix that Collagen I binds to plus the ratio of Collagen III to I decreases as we mature. This modifying ratio is thought to lead on the shifting feel and look of skin after a while. Being able to promote the creation of Collagen III and I is what will make Protinol™ so Exclusive.
Right up until now, only collagen one has long been proficiently restored through topical skincare, but with no matrix of ‘child collagen’- the influence is small. Avon’s new breakthrough patented component*, Protinol™, operates to revive both collagen one AND collagen three, bringing them nearer to that optimal ratio found in newborn skin.
Nakon jedne ampule vaša koža izgleda svježe i hidratizirano, nakon tri elastično, pomlađeno i zdravije, a nakon sedam ampula bore su vidljivo zaglađenije, koža je čvršća i elastičnija te zdravog sjaja.
The appeal of Protinol™ is its power to convey These two kinds of collagens together, meaning it is possible to assume to check out results like firmer-feeling skin in just seven times* – wow.
The results of this marketplace breakthrough is your best skin in several years, shifting nearer to how your skin functioned as being a baby. Your skin, reborn.
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